Cole Lab

My laboratory uses analytical ultracentrifugation and other biophysical techniques to study macromolecular interactions that regulate the interferon antiviral defense pathway and replication of HIV and Hepatitis C viruses. Current research opportunities focus on PKR, an antiviral kinase that is activated by double-stranded RNA

 

We currently have openings for students to work on the following projects:

• Mechanism of activation and inhibition of PKR by viral RNAs and proteins.

• Structural analysis of PKR by small angle X-ray and neutron scattering.

• Interaction of PKR with substrates and host factors.