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Faculty
Structural
Biology and Biophysics Faculty
- Andrei
Alexandrescu -- High-resolution
solution NMR investigations of protein structure, folding, dynamics,
and association; NMR methods to investigate residual structure
in protein folding intermediates; conserved folding mechanisms
of proteins that share the OB-fold structural motif; evolution
of protein structure; structures of neuromuscular junction components;
NMR methods to study amyloid fibrils; computational approaches
to protein folding.
--->Personal
Lab Web Site
--->Research
Projects Available
- Peter
Burkhard -- Structure - based rational design
of small proteins that are able to self-assemble into nanoparticles
with icosahedral symmetry. We are investigating the biophysical
properties and the medical applications of such nanoparticles.
Functionalized nanoparticles are being designed for as drug targeting
and delivery systems. Synthetic vaccines are being developed by
using these nanoparticles as repetitive antigen display systems
--->Personal
Lab Web Site
--->Research
Projects Available
- James
Cole -- Biophysical characterization
of noncovalent protein-protein, protein-nucleic acid, and protein-ligand
interactions using analytical ultracentrifugation and related
techniques. We are studying the mechanism of activation of protein
kinase R (PKR) using biophysical and structural methods. Other
research interests include: dsRNA binding motifs, proteins of
the interferon host defense pathway, the trp RNA attenuation protein
of Bacillus subtilis, HIV integrase and HIV gp41.
--->Personal
Lab Web Site
--->Research
Projects Available
- Victoria
Robinson -- High-resolution determination of protein
structures by X-ray crystallography. The goal of my research is
to use genetic, biochemical and structural methodologies to study
novel families of bacterial GTPases, which have potential as targets
for antimicrobial development.
--->Personal
Lab Web Site
--->Research
Projects Available
Affiliated
Faculty
- Arlene
Albert -- The effect of lipids on the structure and function
of membrane proteins. Specifically, the structure of the G-protein
receptor, rhodopsin, its interaction with lipids and the role
which the lipid bilayer composition plays in modulating the biochemistry
of visual signal transduction
- Debra
Kendall -- Biochemical and biophysical analyses of membrane-interactive
proteins to probe the relationship between structural properties
and biological function; examination of signal peptides and protein
export in prokaryotes; analyses of membrane protein folding and
assembly; mapping the active site(s) of the cannabinoid receptor
and signal transduction studies of this G-protein coupled receptor.
- Carolyn
Teschke -- Biochemical, biophysical, and mutational analysis
of protein folding in vivo and in vitro, specifically of proteins
greater than 400 amino acids in length; interaction of folding
intermediates with molecular chaperones; kinetics and specificity
of aggregation reactions, virus assembly.
Emeritus Faculty
- Emory
Braswell (Emeritus) -- Physical chemistry and charge of
macromolecules and their interaction with other molecules using
analytical ultracentrifugation light-scattering, and computer
simulation studies.
- Judith
Kelly (Emeritus) -- Protein structure and function using
techniques of X-ray diffraction, kinetic methods and interactive
computer graphics. Drug inhibition of enzyme catalysis; protein-protein
interactions; investigation of enzyme mechanisms at the atomic
level; high-speed, three-dimensional graphics modelling of biological
marcomolecules.
- James
R. Knox (Emeritus) -- Biophysical and stereochemical analysis
of 3D macromolecular structure, especially by means of x-ray scattering
and protein crystallography. The tertiary structures and enzymic
mechanisms of several bacterial drug targets are being established
in an effort to assist medicinal chemists in drug/inhibitor design.
Current enzymes under study are the beta- lactamases and transpeptidases
which interact with penicillin-type antibiotics, and two D-alanyl
ligases of cell wall synthesis which are potential targets of
new drugs.
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